Genetic algorithms | Regression analysis

Linkage disequilibrium score regression

In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic effects and various confounding factors, such as population stratification, based on summary statistics from genome-wide association studies (GWASs). The approach involves using regression analysis to examine the relationship between linkage disequilibrium scores and the test statistics of the single-nucleotide polymorphisms (SNPs) from the GWAS. Here, the "linkage disequilibrium score" for a SNP "is the sum of LD r2 measured with all other SNPs". LDSC can be used to produce SNP-based heritability estimates, to partition this heritability into separate categories, and to calculate genetic correlations between separate phenotypes. Because the LDSC approach relies only on summary statistics from an entire GWAS, it can be used efficiently even with very large sample sizes. In LDSC, genetic correlations are calculated based on the deviation between chi-square statistics and what would be expected assuming the null hypothesis. (Wikipedia).

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RELATIONSHIPS Between Variables: Standardized Covariance (7-1)

Correlation is a way of measuring the extent to which two variables are related. The term correlation is synonymous with “relationship.” Variables are related when changes in one variable are consistently associated with changes in another variable. Dr. Daniel reviews Variance, Covariance,

From playlist Correlation And Regression in Statistics (WK 07 - QBA 237)

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Estimate the Correlation Coefficient Given a Scatter Plot

This video explains how to estimate the correlation coefficient given a scatter plot.

From playlist Performing Linear Regression and Correlation

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Multiple loci (1), linkage disequilibrium.

This video extends the single-locus two-allele ideas from the previous videos to two loci with two alleles and looks at situations in which the alleles present at the different loci may not be independent of one another. This "linkage disequilibrium" is reduced over time by recombination h

From playlist TAMU: Bio 312 - Evolution | CosmoLearning Biology

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Covariance (12 of 17) Covariance Matrix wth 3 Data Sets and Correlation Coefficients

Visit http://ilectureonline.com for more math and science lectures! To donate:a http://www.ilectureonline.com/donate https://www.patreon.com/user?u=3236071 We will find the correlation coefficients of the 3 data sets form the previous 2 videos. Next video in this series can be seen at:

From playlist COVARIANCE AND VARIANCE

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Nicola Armstrong - Genome-Wide Association Studies and beyond

Associate Professor Nicola Armstrong (Murdoch University) presents “Genome-Wide Association Studies and beyond”, 22 October 2020 (seminar organised by ANU).

From playlist Statistics Across Campuses

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Covariance (14 of 17) Covariance Matrix "Normalized" - Correlation Coefficient

Visit http://ilectureonline.com for more math and science lectures! To donate:a http://www.ilectureonline.com/donate https://www.patreon.com/user?u=3236071 We will find the “normalized” matrix (or the correlation coefficients) from the covariance matrix from the previous video using 3 sa

From playlist COVARIANCE AND VARIANCE

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Univariate and Multivariate selection by Bruce Walsh

Second Bangalore School on Population Genetics and Evolution URL: http://www.icts.res.in/program/popgen2016 DESCRIPTION: Just as evolution is central to our understanding of biology, population genetics theory provides the basic framework to comprehend evolutionary processes. Population

From playlist Second Bangalore School on Population Genetics and Evolution

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Covariance (8 of 17) What is the Correlation Coefficient?

Visit http://ilectureonline.com for more math and science lectures! To donate:a http://www.ilectureonline.com/donate https://www.patreon.com/user?u=3236071 We will learn what is and how to find the correlation coefficient of 2 data sets and see how it corresponds to the graph of the data

From playlist COVARIANCE AND VARIANCE

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Scatterplots, Part 3: The Formula Behind the Correlation Coefficient

We use the Scatterplots & Correlation app to explain the formula behind the correlation coefficient. The app allows you to find and plot the z-scores, showing the 4 quadrants in which points on the scatterplot can fall.

From playlist Chapter 3: Relationships between two variables

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Lecture 13: Case Hx: Complex Traits

MIT HST.512 Genomic Medicine, Spring 2004 Instructor: Dr. Scott Weiss View the complete course: https://ocw.mit.edu/courses/hst-512-genomic-medicine-spring-2004/ YouTube Playlist: https://www.youtube.com/watch?v=_-gQchCLmXk&list=PLUl4u3cNGP613PJMNmRjAIdBr76goU1V5 We're going to begin by

From playlist MIT HST.512 Genomic Medicine, Spring 2004

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David Heckerman, Microsoft - Stanford Big Data 2015

Bringing together thought leaders in large-scale data analysis and technology to transform the way we diagnose, treat and prevent disease. Visit our website at http://bigdata.stanford.edu/.

From playlist Big Data in Biomedicine Conference 2015

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Multiple loci (2), hitchhiking.

This video looks at the effects of selection on an allele at one locus can influence the diversity and fixation of alleles at a nearby neutral locus due to "hitchhiking."

From playlist TAMU: Bio 312 - Evolution | CosmoLearning Biology

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Using structure to select features in high dimension. - Azencott - Workshop 3 - CEB T1 2019

Chloé-Agathe Azencott (Mines-Paristech) / 02.04.2019 Using structure to select features in high dimension. Many problems in genomics require the ability to identify relevant features in data sets containing many more orders of magnitude than samples. This setup poses different statistic

From playlist 2019 - T1 - The Mathematics of Imaging

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How to find correlation in Excel with the Data Analysis Toolpak

Click this link for more information on correlation coefficients plus more FREE Excel videos and tips: http://www.statisticshowto.com/what-is-the-pearson-correlation-coefficient/

From playlist Regression Analysis

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Molecular evolution (1), introduction.

This video revisits some of the concepts from the previous lectures about population genetics from a perspective in which the alleles are defined as specific changes to the DNA nucleotides rather than abstract differences between alleles. Some new topics are also introduced. Topics describ

From playlist TAMU: Bio 312 - Evolution | CosmoLearning Biology

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Chiara Sabatti: Knockoff genotypes: value in counterfeit

CIRM VIRTUAL EVENT Recorded during the meeting "Mathematical Methods of Modern Statistics 2" the June 05, 2020 by the Centre International de Rencontres Mathématiques (Marseille, France) Filmmaker: Guillaume Hennenfent Find this video and other talks given by worldwide mathematicians

From playlist Virtual Conference

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ICTS Special Colloquium by Wolfgang Stephan

Second Bangalore School on Population Genetics and Evolution URL: http://www.icts.res.in/program/popgen2016 DESCRIPTION: Just as evolution is central to our understanding of biology, population genetics theory provides the basic framework to comprehend evolutionary processes. Population

From playlist Second Bangalore School on Population Genetics and Evolution

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Ex: Matching Correlation Coefficients to Scatter Plots

This video provides several examples of how to match the value of a correlation coefficient to a scatter plot. Site: http://mathispower4u.com

From playlist TI-84: Regression on the Graphing Calculator

Related pages

Confounding | Coefficient of determination | Regression analysis | Summary statistics | Test statistic | Null hypothesis