Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is sometimes referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals including peptides and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed. The phrase "drug design" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles. (Wikipedia).
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From playlist Design Thinking
Design thinking can improve anything from a water bottle to a community water system. See how design thinking improves the creative process, from Professor Stefanos Zenios: http://stanford.io/1mgkHGR
From playlist More
In this video, you’ll learn how to broaden your definition of design through critical thinking, in order to see it in the world around you! Visit https://www.gcflearnfree.org/ to learn even more. We hope you enjoy!
From playlist Graphic Design
System Design Interview: A Step-By-Step Guide
Learn something new every week by subscribing to our newsletter: https://bit.ly/3tfAlYD Checkout our bestselling System Design Interview books: Volume 1: https://amzn.to/3Ou7gkd Volume 2: https://amzn.to/3HqGozy ABOUT US: Covering topics and trends in large-scale system design, from th
From playlist System Design Interview
If you are interested in learning more about this topic, please visit http://www.gcflearnfree.org/ to view the entire tutorial on our website. It includes instructional text, informational graphics, examples, and even interactives for you to practice and apply what you've learned.
From playlist Graphic Design
What Do Graphic Designers Do?: Understanding Design
According to the American Institute of Graphic Arts, graphic designers practice the art of projecting ideas and experiences with visual and textual content. Graphic designers use a range of tools to convey information in aesthetically pleasing and legible formats. Join Prasad Boradkar, a
From playlist Understanding Design
Building A Product From The Ground Up
For most seasoned business owners and aspiring entrepreneurs, the product development process often carries a mystical aura. Product development refers to the complete process of taking a product to market. It also covers renewing an existing product and introducing an old product to a new
From playlist Product Development
Take the full course: https://www.systemsinnovation.network/courses/7357542/ Twitter: http://bit.ly/2JuNmXX LinkedIn: http://bit.ly/2YCP2U6 Design thinking is a design process that enables us to solve complex problems. It combines deep end-user experience, systems thinking, iterative rapid
From playlist More
What is Beauty in Design?: Understanding Design
Designers strive to fill up the world with beautiful environments, packaging, products and landscapes. These can be defined as aesthetic experiences wherein designers use the study of beauty to create pleasurable experiences for humans to interact with items and spaces. Join Prasad Borad
From playlist Understanding Design
12. Biomolecular Engineering: General Concepts (cont.)
Frontiers of Biomedical Engineering (BENG 100) Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a d
From playlist Frontiers of Biomedical Engineering with W. Mark Saltzman
Not All Drugs Get Approved the Same Way: Exceptions to FDA Rules
All drugs have to follow the same path to approval at the US Food and Drug Administration, except when they don't. Today, with the support of NIHCM, we're learning about the exceptions to the rules that can happen when drugs get approved. The FDA has several alternate pathways that can hel
From playlist How Drugs Get Approved
Unmet needs in regulatory science for generic drugs
Robert Lionberger, Ph.D., Director of the Office of Research and Standards in the Office of Generic Drugs (OGD) at the FDA describes regulatory science initiatives of OGD and unmet needs for generic drugs.
From playlist UCSF-Stanford CERSI Lecture Series
I finish my lecture on Experimental Design with an introduction to Block Design, Matched Pairs Design, and Double Blind Experiments. Check out http://www.ProfRobBob.com, there you will find my lessons organized by class/subject and then by topics within each class. Find free review test,
From playlist AP Statistics
How AI Can Save Lives | SciShow Compilation
Visit http://brilliant.org/scishow/ to get started learning STEM for free, and the first 200 people will get 20% off their annual premium subscription. Artificial intelligence is rapidly becoming an integral part of our everyday lives. Here’s a number of ways in which it manages to make l
From playlist Uploads
High Speed Protein Simulations with Anton
Anton: A Special-Purpose Machine That Achieves a Hundred-Fold Speedup in Biomolecular Simulations" Molecular dynamics (MD) simulation has long been recognized as a potentially transformative tool for understanding the behavior of proteins and other biological macromolecules, and for develo
From playlist AI talks
30. Esomeprazole as an Example of Drug Testing and Usage
Freshman Organic Chemistry (CHEM 125) The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryn
From playlist Freshman Organic Chemistry with J. Michael McBride
Systems Approaches for Combinatorial Biology - S. Chandrasekaran - 1/14/16
Bioinformatics Research Symposium Beckman Institute Auditorium Thursday, January 14, 2016
From playlist Bioinformatics Research Symposium
We’re Teaching Robots and AI to Design New Drugs
September Pin of the Month: https://store.dftba.com/collections/scishow/products/scishow-pin-of-the-month-chandra-x-ray-observatory-september It might sound like a concept from science fiction, but artificial intelligence is already facilitating the development process behind some pharma
From playlist Uploads
What Is Industrial Design?: Understanding Design
Industrial design, which is also known as product design, is the creation of consumer goods, from the smallest spoon to the largest machine. Industrial designers seek to optimize the function, value and appearance of products and systems. Join Prasad Boradkar, a professor emeritus of ind
From playlist Understanding Design
The Woman Who Changed Drug Development
From a new method of drug design to an antiviral agent for herpes, Gertrude Elion's works totally transformed the world of drug development. Hosted by: Michael Aranda SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at http://www.scishowtangents.org ---------- Su
From playlist Uploads