A protonophore, also known as a proton translocator, is an ionophore that moves protons across lipid bilayers or other type of membranes. This would otherwise not occur as protons cations (H+) have positive charge and hydrophilic properties, making them unable to cross without a channel or transporter in the form of a protonophore. Protonophores are generally aromatic compounds with a negative charge, that are both hydrophobic and capable of distributing the negative charge over a number of atoms by π-orbitals which delocalize a proton's charge when it attaches to the molecule. Both the neutral and the charged protonophore can diffuse across the lipid bilayer by passive diffusion and simultaneously facilitate proton transport. Protonophores uncouple oxidative phosphorylation via a decrease in the membrane potential of the inner membrane of mitochondria. They stimulate mitochondria respiration and heat production. Protonophores (uncouplers) are often used in biochemistry research to help explore the bioenergetics of chemiosmotic and other membrane transport processes. It has been reported that the protonophore has antibacterial activity by perturbing bacterial proton motive force. Representative anionic protonophores include: * 2,4-dinitrophenol * Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) * Carbonyl cyanide m-chlorophenyl hydrazone (CCCP) Representative cationic protonophores include: * C4R1 (a short-chain alkyl derivative of rhodamine 19) * Ellipticine Representative zwitterionic protonophores include: * mitoFluo (10-[2-(3-hydroxy-6-oxo-xanthen-9-yl)benzoyl]oxydecyl-triphenyl-phosphonium bromide) * PP6 (2-(2-Hydroxyaryl)hexylphosphonium bromide) (Wikipedia).
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From playlist Science Unplugged: Particle Physics
Discovery of the Proton | Open Questions in Nuclear Physics
The proton is an important building block of all matter around us and was long thought to be a fundamental particle. In this video, we will talk about its discovery in the early 20th century. References: [1] C. A. Bertulani, "Nuclear Physics in a Nutshell" (2007). [2] https://en.wikipe
From playlist Particle Physics
Can You Believe It? #19 The Structure of a Proton
Visit http://ilectureonline.com for more math and science lectures! To donate: http://www.ilectureonline.com/donate https://www.patreon.com/user?u=3236071 We will learn the intricate structure of a proton at the level of the gluon and quarks. Previous video in this series can be seen at
From playlist CAN YOU BELIEVE IT?
Nucleophiles and Electrophiles
This organic chemistry video tutorial provides a basic introduction into nucleophiles and electrophiles. Nucleophiles are lewis bases and electrophiles are lewis acids. Organic Chemistry 1 Review - 100 Practice Problems: https://bit.ly/2WCJ8GP New Organic Chemistry Playlist https://www
From playlist New Organic Chemistry Playlist
The Atom A1 Rutherford Scattering
The discovery of the nucleus of the atom.
From playlist Physics - The Atom
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From playlist Science Unplugged: Neutrinos
Homotopic, Enantiotopic, Diastereotopic, and Heterotopic Protons
In doing NMR spectroscopy, we must be able to predict chemical shifts for a variety of protons. When comparing specific pairs of protons, we can assign them a few different relationships, those being homotopic, enantiotopic, diasteretopic, and heterotopic. Let's see what these words mean a
From playlist Organic Chemistry
Acids and Bases - Short Revision || CBSE Science || || Infinity Learn Class 9&10
Acids and bases are two types of substances that are fundamental to chemistry. An acid is a substance that donates protons (hydrogen ions, H+) to a solution, while a base is a substance that accepts protons or donates hydroxide ions (OH-) to a solution. There are several ways to define and
From playlist Shorts
We've been hearing about DNA since the third grade, and we all know that it's a double helix with little ladder rungs. But now we are ready to understand this molecule on a more fundamental level, which will enable to us to understand how this molecule can serve as the genetic code. Let's
From playlist Biochemistry