Plakohypaphorines are halogenated indolic non-proteinogenic amino acids named for their similarity to hypaphorine (N,N,N-trimethyltryptophan). First reported in the Caribbean sponge Plakortis simplex in 2003, plakohypaphorines A-C were the first iodine-containing indoles to be discovered in nature. Plakohypaphorines D-F, also found in P. simplex, were reported in 2004 by a group including the researchers who discovered the original plakohypaphorines. (Wikipedia).
Total Synthesis of ent-Plagiochianin B
An organic chemistry minilecture on the Total Synthesis of ent-Plagiochianin B by Richard K. Jackson III and John L. Wood*. It features a creative azatriene electrocyclization pyridine synthesis, an exo-alkene selective palladium catalysed oxidation and an endo-alkene selective iron catal
From playlist Total Synthesis
An organic chemistry minilecture on 'A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization' by John F. Hoskin and Erik J. Sorensen*. Highlights include a Photoenolization- Diels−Alder reaction and a photoepimerization. SUPPORT THE CHANNEL ON PATREON: https://ww
From playlist Total Synthesis
An organic chemistry minilecture on the Synthesis of Pleuromutilin by Nicholas J. Foy and Sergey V. Pronin*. It features a Hydrogen Atom Transfer cyclization , reductive cyclization with Sato's reagent and a Photodecarboxylation-Fragmentation reaction SUPPORT THE CHANNEL ON PATREON: ht
From playlist Total Synthesis
The Final Steps of Making Pyrimethamine ("Daraprim")
In this video we finally make Pyrimethamine. Pyrimethamine is also known as Daraprim. Related videos: Make 2-(p-chlorophenyl)-3-oxopentanenitrile: https://www.youtube.com/watch?v=5oAZyhPx_ws Getting Guanidine Carbonate and Hydrochloride from No-Lye Hair Relaxants: https://www.youtube.
From playlist Pyrimethamine
Total Synthesis of Dysifragilone A, B and Dysidavarone C
An organic chemistry minilecture on the Total Synthesis of Dysifragilone A, B and Dysidavarone C by Yang-Ming Li, Yu-Tong Sun, Bi-Yuan Li, Hong-Bo Qin* Highlights include a reductive Heck coupling, palladium-catalysed α-arylation reaction and a dissolving metal enolate addition. NB: Reup
From playlist Total Synthesis
Make p-chlorobenzyl chloride (from para-chlorotoluene) 3rd step in making pyrimethamine
In this video we synthesize p-chlorobenzyl chloride from para-chlorotoluene we made in an earlier video. ----------------------------------------------------------------------------------------------------- Glassware generously provided by http://www.alchemylabsupply.com/ Use the disco
From playlist Pyrimethamine
Synthesis of a Bromoalkane (n-Bromopropane)
In this video, I will be making n-bromopropane by brominating 1-propanol. The n-bromopropane can then be used in a Grignard reaction to make butyric acid (smell of vomit). Here is the video of me using it in a Grignard reaction: http://youtu.be/_wmx65zQk58 This process can be used as a
From playlist Syntheses and Demonstrations
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From playlist Science Unplugged: General Relativity
REUPLOAD - Make 2-(p-chlorophenyl)-3-oxopentanenitrile - Step 5 in Pyrimethamine Synthesis
In this video we make 2-(p-chlorophenyl)-3-oxopentanitrile which is step 5 in our synthesis of Pyrimethamine Related videos: Drying alcohol: https://www.youtube.com/watch?v=NMfs3e9OdZQ Making sodium metal with domestically available chemicals: https://www.youtube.com/watch?v=jCrFFVVcPU
From playlist Pyrimethamine
From playlist the absolute best of stereolab