Perifosine (also KRX-0401) is a former drug candidate that was under development for a variety of cancer indications. It is an alkyl-phospholipid structurally related to miltefosine. Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin homology domain of AKT. It was being developed by Keryx Biopharmaceuticals who had licensed it from Inc. In 2010, perifosine received orphan drug status in the U.S. for the treatment of multiple myeloma and neuroblastoma, and for multiple myeloma in the EU. However, both were later withdrawn. In 2011 it was in a phase III trial for colorectal cancer, and another for multiple myeloma. On April 2, 2012, it was announced that perifosine failed its phase III clinical trial for treatment of colon cancer. Detailed results were released in June 2012. On March 11, 2013 Aeterna Zentaris announced the discontinuing of Phase 3 clinical trial of perifosine for the treatment of relapsed and refractory multiple myeloma. (Wikipedia).
Epoxidation of Alkenes - DMDO, mCPBA, & NaOCl (IOC 26)
In this episode, I discuss the epoxidation of electron-rich and electron-poor olefins, using peracids, DMDO, hydrogen peroxide, and sodium hypochlorite (NaOCl). *Note: for some reason, I didn't manage to pronounce MMPP correctly; it's full name is magnesium monoperoxyphthalate. *WARNING*
From playlist Organic Chemistry Lectures
Making Calcium Peroxide (CaO2)
In today’s video we are making calcium peroxide from sodium hydroxide, calcium chloride and hydrogen peroxide. Calcium peroxide is an oxidizing agent and it could be used to make oxygen by simply heating it. Our yield was low but we managed to make some. Just to put it somewhere: the produ
From playlist Inorganic Chemistry
What is Polypropylene and what is it used for?
From wiki: Polypropylene, also known as polypropene, is a thermoplastic polymer used in a wide variety of applications. It is produced via chain-growth polymerization from the monomer propylene. Polypropylene belongs to the group of polyolefins and is partially crystalline and non-polar. W
From playlist Materials Sciences 101 - Introduction to Materials Science & Engineering 2020
Total Synthesis of Dysifragilone A, B and Dysidavarone C
An organic chemistry minilecture on the Total Synthesis of Dysifragilone A, B and Dysidavarone C by Yang-Ming Li, Yu-Tong Sun, Bi-Yuan Li, Hong-Bo Qin* Highlights include a reductive Heck coupling, palladium-catalysed α-arylation reaction and a dissolving metal enolate addition. NB: Reup
From playlist Total Synthesis
Everything you ever wanted to know about perovskite
From silicates to semiconductors, here’s why one crystal structure is so prevalent in modern research. See the whole special issue in Science here ($): http://scim.ag/2zPj3EF
From playlist Research Features
How Peroxides Form in Common Reagents
In this video, I discuss the formation of peroxides in common solvents. Make sure you check with the guidelines from your institutional EH&S department before dealing with peroxide-forming solvents! https://www.patreon.com/thatchemist Community Discord - https://discord.gg/QWNPETtPcZ --
From playlist Chemistry Wisdom
Different reactions present in a phase diagram
eutectic, peritectic, eutectoid, peritectoid. These are all different types of reactions that can exist in a phase diagram. Here we go over these and demonstrate which is which.
From playlist Materials Sciences 101 - Introduction to Materials Science & Engineering 2020
What Is Thermosetting and Thermosoftening Polymers | Organic Chemistry | Chemistry | FuseSchool
Learn the basics about thermosetting and thermosoftening polymers, when learning about polymers as a part of organic chemistry. A polymer is a macromolecule made of many monomers, or repeating units. The properties of these polymers depend on a variety of factors – the monomer unit, the
From playlist CHEMISTRY
Chemical Reactions (4 of 11) Decomposition Reactions, An Explanation
Describes the basics of decomposition reactions, how to identify them, predict the products and balance the chemical equation. Two examples are also shown, decomposition of sugar and hydrogen peroxide. A chemical reaction is a process that leads to the chemical change of one set of chemic
From playlist Chemical Reactions and Stoichiometry
The First Real Life Pictures EVER of Perfluorocubane
Take a look at the first pictures of perfluorocubane! In this video I discuss the recent synthesis of perfluorocubane. I want to give a huge thank you to Midori Akiyama and Masafumi Sugiyama for allowing me to share their beautiful photos of perfluorocubane and its precursors. For inquiri
From playlist Remarkable Chemistry