Late-stage functionalization (LSF) is a desired, chemical or biochemical, chemoselective transformation on a complex molecule to provide at least one analog in sufficient quantity and purity for a given purpose without needing the addition of a functional group that exclusively serves to enable said transformation. Molecular complexity is an intrinsic property of each molecule and frequently determines the synthetic effort to make it. LSF can significantly diminish this synthetic effort, and thus enables access to molecules, which would otherwise not be available or too difficult to access. The requirements for LSF can be met by both C–H functionalization reactions and functional group manipulations. LSF reactions are particularly relevant and often used in the fields of drug discovery and materials chemistry, although no LSF has been implemented in a commercial process. (Wikipedia).
The Benefits of Functional Architectures | Systems Engineering, Part 3
See the other videos in this series: https://www.youtube.com/playlist?list=PLn8PRpmsu08owzDpgnQr7vo2O-FUQm_fL Functional, logical, and physical architectures are important tools for designing complex systems. We describe what architectures are and how they contribute to the early stages of
From playlist Systems Engineering
Cellular Respiration Part 3: The Electron Transport Chain and Oxidative Phosphorylation
The trilogy is finally concluded! And with a bang, no less, as this final stage of cellular respiration is the one that provides the big energy payoff for the cell. Let's learn about how the products of the Citric Acid cycle go on to the electron transport chain to facilitate reactions tha
From playlist Biochemistry
The Essence of Functional Programming
This talk dives into the origins of functional programming, going all the way back to where the term was first introduced, to see how it evolved over time into our modern understanding of what FP essentially involves. PUBLICATION PERMISSIONS: Original video was published with the Creative
From playlist Functional Programming
What is Functional Programming?
We will discuss the state of functional programming in brief across several languages. Also a discussion on the broader goals of functional programming and this meetup. EVENT: OKC FP 2020 SPEAKER: Scott Murphy PUBLICATION PERMISSIONS: The conference organizer provided Coding Tech wit
From playlist Functional Programming
Functional Programming for Beginners: Pure Functions Explained
Why is it that pure functions can’t use mutable states in most cases, and how do you fight mutability by working with immutable values? Check it out in this live coding session by Michal Plachta, the author of Grokking Functional Programming. Watch the full video at: http://mng.bz/J24a 📚
From playlist Functional Programming
Don’t Be Scared Of Functional Programming
As software becomes more and more complex, it is more and more important to structure it well. Well-structured software is easy to write, easy to debug, and provides a collection of modules that can be re-used to reduce future programming costs. Conventional languages place conceptual limi
From playlist Functional Programming
Synthesis Workshop: Late-stage Oxidative C(sp3)–H Methylation with Dr. Kaibo Feng (Episode 49)
In this Research Spotlight episode, we're joined by Dr. Kaibo Feng, who takes us through his work on late-stage oxidative C-H methylation. Parent reference: Feng, K.†; Quevedo, R. E.†; Kohrt, J. T.; Oderinde, M. S.; Reilly, U.; White, M. C. Nature 2020, 580, 621. Additional references (i
From playlist Special Topics: Organometallics
19. Disease Progression Modeling and Subtyping, Part 2
MIT 6.S897 Machine Learning for Healthcare, Spring 2019 Instructor: David Sontag View the complete course: https://ocw.mit.edu/6-S897S19 YouTube Playlist: https://www.youtube.com/playlist?list=PLUl4u3cNGP60B0PQXVQyGNdCyCTDU1Q5j Prof. Sontag begins with a recap of the goal of disease progr
From playlist MIT 6.S897 Machine Learning for Healthcare, Spring 2019
CCHF VS 12.2 - Dr Shane Krska | Applications of C–H Functionalization in Drug Discovery
In this video Dr Shane Krska from Merk & Co., Inc., presents on applications of C–H functionalization in drug discovery
From playlist CCHF Virtual Symposia
Synthesis Workshop: Late-Stage C–H Oxygenation And Iodination with Lalita Tanwar (Episode 54)
In this Research Spotlight episode, we're joined by Lalita Tanwar of the Ritter Group, who shares with us her work on late-stage C-H oxygenation and iodination. Parent references: J. Am. Chem. Soc. 2018, 140, 16026-16031. J. Am. Chem. Soc. 2019, 141, 17983–17988. Org. Lett. 2021, 23, 5024
From playlist Research Spotlights
CCHF VS 14.1 - Prof. Richmond Sarpong
Prof. Richmond Sarpong from UC Berkeley talks about his group's work in chemical synthesis inspired by complex molecules.
From playlist CCHF Virtual Symposia
Synthesis Workshop: Iron-catalyzed Azidation with Craig Day (Episode 92)
In this Research Spotlight episode, Craig Day (PhD researcher in Martin group, ICIQ/visiting researcher in Hartwig group, UC Berkeley) joins us to share his mechanistic work on iron-catalyzed azidation of alkyl C(sp3)-H bonds with Zhdankin’s l3-azidoiodane. Key reference: J. Am. Chem. Soc
From playlist Special Topics: Organometallics
Jet Quenching and Early-time Dynamics by Bin Wu
DISCUSSION MEETING EXTREME NONEQUILIBRIUM QCD (ONLINE) ORGANIZERS: Ayan Mukhopadhyay (IIT Madras) and Sayantan Sharma (IMSc Chennai) DATE & TIME: 05 October 2020 to 09 October 2020 VENUE: Online Understanding quantum gauge theories is one of the remarkable challenges of the millennium
From playlist Extreme Nonequilibrium QCD (Online)
The Surprisingly Dynamic...Massive Stars - Eliot Quataert
Joint IAS/Princeton University Astrophysics Colloquium Tuesday, October 27, 2015 http://www.sns.ias.edu/~seminar/colloquia.shtml In the last few years of the lives of massive stars, fusion in the core of the star produces a nuclear power that greatly exceeds the Eddington luminosity. Thi
From playlist Joint IAS/PU Astrophysics Colloquium
Equilibration of the QGP and it’s Phenomenological Consequences by Sören Schlichting
DISCUSSION MEETING EXTREME NONEQUILIBRIUM QCD (ONLINE) ORGANIZERS: Ayan Mukhopadhyay (IIT Madras) and Sayantan Sharma (IMSc Chennai) DATE & TIME: 05 October 2020 to 09 October 2020 VENUE: Online Understanding quantum gauge theories is one of the remarkable challenges of the millennium
From playlist Extreme Nonequilibrium QCD (Online)
CCHF VS 1.1 | Prof. Stoltz: Silylation of C–H bonds in aromatic heterocycles
Silylation of C–H bonds in aromatic heterocycles by an earth abundant metal catalyst Prof. Brian Stoltz California Institute of Technology
From playlist CCHF Virtual Symposia
http://www.teachastronomy.com/ A major step in the development of life is the transition from free floating organic molecules in water to cells. Biology cannot develop without some form of compartment or membrane to concentrate chemical reactions and protect the entity from the environmen
From playlist 25. Early Earth and Life Processes
Late-Stage and Strain-Accelerated Oxidation Enabled Synthesis of Haouamine A- Part Two
An organic chemistry lecture on the Late-Stage and Strain-Accelerated Oxidation Enabled Synthesis of Haouamine A by Kun Ho (Kenny) Park, Antonio Rizzo and David Y.-K. Chen*. It features a Rh-catalysed diazo insertion, macrocyclization and highly selective oxidation reactions to form a stra
From playlist Total Synthesis