DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening on unprecedented scale of collections of small molecule compounds. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification. DEL technology involves the conjugation of chemical compounds or building blocks to short DNA fragments that serve as identification bar codes and in some cases also direct and control the chemical synthesis. The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized protein target. A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. In contrast to conventional screening procedures such as high-throughput screening, biochemical assays are not required for binder identification, in principle allowing the isolation of binders to a wide range of proteins historically difficult to tackle with conventional screening technologies. So, in addition to the general discovery of target specific molecular compounds, the availability of binders to pharmacologically important, but so-far “undruggable” target proteins opens new possibilities to develop novel drugs for diseases that could not be treated so far. In eliminating the requirement to initially assess the activity of hits it is hoped and expected that many of the high affinity binders identified will be shown to be active in independent analysis of selected hits, therefore offering an efficient method to identify high quality hits and pharmaceutical leads. (Wikipedia).
We've been hearing about DNA since the third grade, and we all know that it's a double helix with little ladder rungs. But now we are ready to understand this molecule on a more fundamental level, which will enable to us to understand how this molecule can serve as the genetic code. Let's
From playlist Biochemistry
DNA and RNA - Differences in Form and Function | Stated Clearly
This video comes with a worksheet and slides you can download here: - Free worksheet: https://drive.google.com/file/d/1ST9qN_bKiwxhIxXbl0oAY1qkf7a3c9H6/view?usp=sharing - PowerPoint slides for teachers: https://forms.gle/Qj6LKdd7YtX71J4o9 If you found this video useful, you can always sup
From playlist Genetics and Evolution
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From playlist Biology
This 3D animation shows how proteins are made in the cell from the information in the DNA code. To download the subtitles (.srt) for this site, please use the following link: https://goo.gl/Ew7l69 and for more information, please view the video and explore related resources on our site:
From playlist Biology
Biology Quiz: What is DNA and what does it do?
Ready to make the grade in biology? Subscribe to our new Biology channel to get more quizzes and biology animations! https://bit.ly/3jHu5UP #biology #DNA #shorts
From playlist 1 Minute Biology Quizzes
Year 10 Science DNA structure using lollies A tenuous link to Science Week Food by Design Well this is a design using food . . .
From playlist 10 - Biology
A Level Biology Revision "Nucleotides"
In this video, I take you through the essential information about nucleotides. First I show you the three parts of a nucleotide. I then take you through the differences between the sugars and bases found in the nucleotides which form DNA and RNA. Finally I explain to you how nucleotides ca
From playlist A Level Biology "DNA, RNA and Protein Synthesis"
IB Chemistry HL Option B Biochemistry B.8 Nucleic acids
IB Chemistry HL Option B Biochemistry B.8 Nucleic acids More resources: http://www.mrwengibchemistry.com/ • Nucleotides are the condensation products of a pentose sugar, phosphoric acid and a nitrogenous base—adenine (A), guanine (G), cytosine (C), thymine (T) or uracil (U). • Polynucleo
From playlist Option B Biochemistry SL HL
Introduction to Chemical Biology 128. Lecture 01. Introduction/What is Chemical Biology?
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From playlist Chem 128: Intro to Chem Biology
Introduction to Chemical Biology 128. Lecture 02. Common Tools in Chemical Biology.
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From playlist Chem 128: Intro to Chem Biology
Philipp HOLLIGER - Synthetic genetics
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From playlist Cellular and Molecular Biotechnology
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From playlist Chem 128: Week 5
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Recombinant DNA 2 (Prof. Eric Lander) View the complete course: http://ocw.mit.edu/7-012F04 License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu
From playlist MIT 7.012 Introduction to Biology, Fall 2004
Florian Hollfelder – Bioinspired genotype–phenotype linkages
Florian Hollfelder is based in the Department of Biochemistry at the University of Cambridge. He is interested in mechanism in chemistry and biology. Here he describes using principles of natural selection to make functional proteins. The Royal Society hosted a worldwide scientific discus
From playlist Latest talks and lectures
Richard Murray - CS+Biology - Alumni College 2016
"Synthetic Biology: Programming Cellular Behavior Using DNA" Richard Murray (BS ’85), the Thomas E. and Doris Everhart Professor of Control and Dynamical Systems and Bioengineering, is a leading expert in the field of control theory, an interdisciplinary branch of engineering and mathemat
From playlist Talks and Seminars
Lec 15 | MIT 7.012 Introduction to Biology, Fall 2004
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From playlist MIT 7.012 Introduction to Biology, Fall 2004
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From playlist HST.508 Genomics and Computational Biology, Fall 2002
Tom ELLIS - Engineering Yeast: Synthetic Modularity at the Gene, Circuit, Pathway and Genome Level
Synthetic biology seeks to understand and derive value from biology via its re-design and synthesis using engineering principles. After a decade of work to improve DNA assembly and the control of gene expression, synthetic biology can now tack le cell-scale problems. By applying mod
From playlist Cellular and Molecular Biotechnology
What Is DNA | Genetics | Biology | FuseSchool
What Is DNA | Genetics | Biology | FuseSchool DNA (deoxyribose nucleic acid) is extremely important. All living things have DNA, or in the case of some viruses they have RNA instead. In eukaryotes, it is found within the nucleus and is arranged into chromosomes. DNA determines the chara
From playlist BIOLOGY: Genetics