The bump-and-hole method is a tool in chemical genetics for studying a specific isoform in a protein family without perturbing the other members of the family. The unattainability of isoform-selective inhibition due to structural homology in protein families is a major challenge of chemical genetics. With the bump-and-hole approach, a protein–ligand interface is engineered to achieve selectivity through steric complementarity while maintaining biochemical competence and orthogonality to the wild type pair. Typically, a "bumped" ligand/inhibitor analog is designed to bind a corresponding "hole-modified" protein. Bumped ligands are commonly bulkier derivatives of a cofactor of the target protein. Hole-modified proteins are recombinantly expressed with an amino acid substitution from a larger to smaller residue, e.g. glycine or alanine, at the cofactor binding site. The designed ligand/inhibitor has specificity for the engineered protein due to steric complementarity, but not the native counterpart due to steric interference. (Wikipedia).
Portal 2 OoB glitch [Laser Platform]: Portal bump
A portal bump oversight in the Laser Platform map. Just something I found randomly. Doesn't seem useful though.
From playlist Portal & Portal 2
3 physics demonstrations Friction on a body at a rotating platform (science experiments)
Amazing Physics Demonstrations (la physique)(experiments)
From playlist MECHANICS
Intersection of Planes on Geogebra
In this video, we look at a strategy for finding the intersection of planes on Geogebra.
From playlist Geogebra
Bearings and Trigonometry problem solving
Challenging A - A* bearings questions incorporating problem solving, angle facts and trigonometry.
From playlist bearings
Fill In The Blank (Dynamics/Friction)
#Physics #Dynamics #Engineering #TikTok #NicholasGKK #shorts
From playlist Mechanical Engineering
Primordial Black Holes from a Tiny Bump/Dip in the Inflaton Potential by Swagat Saurav Mishra
PROGRAM LESS TRAVELLED PATH OF DARK MATTER: AXIONS AND PRIMORDIAL BLACK HOLES (ONLINE) ORGANIZERS: Subinoy Das (IIA, Bangalore), Koushik Dutta (IISER, Kolkata / SINP, Kolkata), Raghavan Rangarajan (Ahmedabad University) and Vikram Rentala (IIT Bombay) DATE: 09 November 2020 to 13 Novemb
From playlist Less Travelled Path of Dark Matter: Axions and Primordial Black Holes (Online)
Physical Science 2.5a - Friction
Friction. What it is and why it occurs.
From playlist Physical Science Chapter 2 (Complete chapter)
Primordial Black Holes as the Solution of Many Cosmological Conundra by Bernard Carr
PROGRAM LESS TRAVELLED PATH OF DARK MATTER: AXIONS AND PRIMORDIAL BLACK HOLES (ONLINE) ORGANIZERS: Subinoy Das (IIA, Bangalore), Koushik Dutta (IISER, Kolkata / SINP, Kolkata), Raghavan Rangarajan (Ahmedabad University) and Vikram Rentala (IIT Bombay) DATE: 09 November 2020 to 13 Novemb
From playlist Less Travelled Path of Dark Matter: Axions and Primordial Black Holes (Online)
From playlist Courses and Series
In this presentation, the key features for System Modeler 12.3, as well as the upcoming release, will be presented. Furthermore, we will show how System Modeler models can be run and used in the Wolfram Cloud and give a brief overview of new model libraries.
From playlist Wolfram Technology Conference 2021
Entanglement Dynamics in 2d CFT: Thomas Hartman
URL: https://strings2015.icts.res.in/talkTitles.php
From playlist Strings 2015 conference
Ahlfors-Bers 2014 "Conformal invariance and critical behavior within critical fractal carpets"
Wendelin Werner (ETH Zürich): Some aspects of conformal invariance can survive within fractal carpets in the plane. In the present talk, I will survey how it is possible to make sense in a rather precise way of certain of these ideas in the special case of certain random -- yet very natura
From playlist The Ahlfors-Bers Colloquium 2014 at Yale
EEVblog #762 - How Secure Are Electronic Safe Locks?
How secure are electronic locks used on safes? Part 3 is where I show 5 ways to crack into a cheap safe! https://www.youtube.com/watch?v=Y6cZrieFw-k Dave tries a basic first attempt power line analysis attack on a standard La Gard (LG) 3740/3750 Basic electronic digital lock on a CMI hom
From playlist Hacking / Experiments
Primordial Black Holes and Small-scale Gravitational Waves in Two-field Models.... by Dhiraj Hazra
PROGRAM LESS TRAVELLED PATH OF DARK MATTER: AXIONS AND PRIMORDIAL BLACK HOLES (ONLINE) ORGANIZERS: Subinoy Das (IIA, Bangalore), Koushik Dutta (IISER, Kolkata / SINP, Kolkata), Raghavan Rangarajan (Ahmedabad University) and Vikram Rentala (IIT Bombay) DATE: 09 November 2020 to 13 Novemb
From playlist Less Travelled Path of Dark Matter: Axions and Primordial Black Holes (Online)
Black Holes and Space Time Explained Using Math - Space Engine/Explain Everything
Hello and welcome to What Da Math! In this video, we will talk about the idea of space time and the folding of space as well as understand what black holes really are. Enjoy the video! Patreon page: https://www.patreon.com/user?u=2318196&ty=h Enjoy and please subscribe. Other videos he
From playlist Space Engine
SHOP TIPS #275 How to Make a Toolmaker's Clamp Pt 1 of 2 tubalcain
In this video #275 part 1 & the next one #276 part 2, I show to make a 4" toolmaker's clamp. Plans will be available from toly upon request. If you want working drawings of this CLAMP project, contact my friend toly. He will send them to you by email & you can print them out on your own p
From playlist #3 MACHINE SHOP TIPS tubalcain playlist #201 thru #300
#Physics #Mechanics #Engineering #NicholasGKK #Shorts
From playlist General Mechanics