Medicinal Chemistry

1. Synthesis of Bioactive Compounds
   1. Organic Synthesis Techniques
      1. Total synthesis
         1. Retrosynthetic analysis
         2. Stepwise synthesis
         3. Asymmetric synthesis
      2. Strategic bond construction
         1. Carbon-carbon bond formation
         2. Carbon-heteroatom bond formation
      3. Functional group transformations
         1. Regioselectivity and stereoselectivity
         2. Protecting group strategies
   2. Combinatorial Chemistry
      1. High-throughput synthesis
         1. Solid-phase synthesis
         2. Solution-phase synthesis
      2. Library design and construction
         1. Split-and-pool method
         2. Scaffold-based approaches
      3. Diversity-oriented synthesis
         1. Scaffold hopping
         2. Fragment assembly
   3. Click Chemistry
      1. Huisgen cycloaddition reactions
      2. Thiol-ene reactions
      3. Strain-promoted azide-alkyne cycloaddition (SPAAC)
      4. Applications in drug discovery
         1. Target identification
         2. Labeling of biomolecules
   4. Green Chemistry Approaches
      1. Principles of green chemistry
         1. Atom economy
         2. Energy efficiency
      2. Solvent alternatives
         1. Supercritical fluids
         2. Ionic liquids
      3. Catalyst development
         1. Enzymatic and biocatalysis
         2. Photocatalysis and electrocatalysis
   5. Scale-up Production
      1. Batch versus continuous flow synthesis
      2. Process optimization
         1. Reaction condition optimization
         2. Yield and purity enhancement
      3. Regulatory and safety considerations
         1. Good manufacturing practices (GMP)
         2. Quality control in large-scale production